Background: One of the most prevalent infections is urinary tract infections, or UTIs. Antimicrobial resistance is one of the most challenging issues a doctor has when treating urinary tract infections. These days, a lot of uropathogens can exhibit antibiotic resistance, which justifies the prudent use of drugs. Objective: The goal is to identify the particular medication for the uropathogens in this tertiary care hospital and investigate the antibiotic sensitivity pattern of uropathogens in that institution. Methods: Patients with suspected UTIs had their urine cultures and sensitivity reports analyzed for this study. Results: 168 of the 561 reports demonstrated increase. Fifty-two (30.95%) of the 168 UTI cases were linked to Escherichia coli, thirty (17.86%) to Klebsiellapneumoniae, twenty-nine (17.26%) to Enterococcus, eleven (6.55%) to Acinetobacter, eleven (6.55%) to Candida species, etc., and thirty-five (20.81%) to more than three. In our investigation, we discovered that Escherichia coli was resistant to ampicillin but sensitive to meropenem and nitrofurantoin. Enterococcus was discovered to be responsive to nitrofurantoin, while Klebsiellapneumoniae was shown to be susceptible to Meropenem but resistant to Ampicillin. It was discovered that Acinetobacter was resistant to Cotrimoxazole, Ciprofloxacin, and Meropenem. Conclusion: The most prevalent uropathogen in this area, Escherichia coli, is susceptible to nitrofurantoin and Meropenem, according to our findings. It has been discovered that Klebsiellapneumoniae is susceptible to Meropenem. Additionally, we can deduce that uropathogens are becoming more resistant to antibiotics. Therefore, taking proactive steps to stop antimicrobial resistance—a threat to global public health—is imperative.