Background:CADis the leading cause of morbidity and mortality worldwide, contributing to the global burden of cardiovascular diseases. The etiology of CAD is multifactorial, involving a combination of genetic, environmental, lifestyle, and biochemical factors. Thyroid dysfunction has a complex relationship with cardiovascular health. Both hypo- and hyperthyroidism can contribute to an increased risk of cardiovascular diseases. Objective: This study aims to evaluate the impact of thyroid dysfunction on cardiovascular risk by comparing lipid profiles, glucose homeostasis, and other risk parameters in hypothyroid, hyperthyroid, and euthyroid CAD patients. Materials and Methods:A total of 150 participants were categorized into hypothyroid, hyperthyroid, and euthyroid groups based on thyroid function tests (TFTs). Comprehensive biochemical analyses, including lipid profiles, fasting blood glucose (FBG), and blood pressure measurements, were performed using automated analyzers. Statistical analyses were conducted using SPSS version 21, with p < 0.05 considered significant. Results: Thyroid dysfunction significantly influenced cardiovascular risk factors. Hypothyroidism was associated with elevated LDL-C, triglycerides, and BMI, along with reduced HDL-C (p < 0.05). Hyperthyroid patients showed lower triglycerides and HDL-C but higher FBG (p < 0.05). Correlation analysis revealed a positive association between TSH and LDL-C (r = 0.90, p = 0.039) and a strong negative association between FT3 and triglycerides (r = -0.99, p = 0.0002). Conclusion: Thyroid dysfunction profoundly impacts lipid metabolism, glucose regulation, and BMI, emphasizing its role as a critical determinant of cardiovascular risk in CAD patients. Regular thyroid function assessments are essential for early identification and intervention to mitigate cardiovascular complications. Future research should explore inflammatory pathways and the longitudinal impacts of thyroid dysfunction on cardiovascular health.