Background: Flumazenil, classified as an imidazobenzodiazepine, serves as a rapid antagonist to the sedative and hypnotic effects induced by benzodiazepines through competitive inhibition at gamma-aminobutyric acid (GABA) receptors. Hence; the present study was conducted for evaluating flumazenil's impact on anaesthesia recovery and bispectral index post sevoflurane/fentanyl anesthesia without premedication at a tertiary hospital. Materials &Methods: A total of 40 patients who were undergoing a surgical procedure were enrolled.Complete demographic and clinical details of all the patients was obtained. The subjects were not premedicated. All the patients were randomized into two study groups with 20 patients in each group; single dose of 0.3 mg of flumazenil (n = 20) or placebo (n = 20). After arrival in the operating room, the subjects' blood pressure, heart rate, electrocardiograph, peripheral oxygen saturation and BIS were continuously measured using a patient monitoring instrument. BIS values were also recorded in two-minute intervals. Statistical analysis was performed using SPSS software. Results: Mean age of the patients of the Flumazenil group and control group was 48.3 years and 46.2 years. Majority proportion of patients were males and were of rural residence. Eye opening on verbal command among patients of the Flumazenil group and Control group was 6.2 minutes and 8.9 minutes respectively. Recovery parameters were significantly better among patients of the flumazenil group.The BIS value was significantly higher in flumazenil group than in the control group beginning 6 min after flumazenil administration. Conclusion:The administration of flumazenil to patients without premedication undergoing anesthesia with sevoflurane and fentanyl may facilitate recovery from anesthesia. This phenomenon could be attributed to flumazenil's ability to counteract the effects of sevoflurane or endogenous benzodiazepines. Nevertheless, a comprehensive study involving a larger sample size may be necessary to more precisely assess the impact and safety of flumazenil in the context of recovery from general anesthesia.