Background: Typhoid fever, a serious systemic infection caused by the Gram-negative bacterium Salmonella enterica serovar Typhi (S. typhi), has remained a major global health issue for centuries. The present study was conducted to assess spectrum of typhoid fever amongst febrile children. Materials & Methods: The study population comprised 150 children admitted to the pediatric ward of, Rama Medical College Hospital and Research Centre, Mandhana, Kanpur, UP. Symptoms, laboratory findings and treatment was recorded in case history. Results: The age distribution shows that the highest incidence was among children aged 5 to 9 years, accounting for 73.33% of the total cases. Fever was seen in 150, chills in 32, headache in 37, nausea in 60, vomiting in 50, loss of appetite in 42, cough in 11 and diarrhea in 40 children. Hemoglobin <10g% was seen in 98, TLC < 4000/cumm in 63, TLC 4000-10000/cumm in 87, raised ESR (>20 mm) in 137, positive widal test in 150, hepatomegaly (USG) in 32, splenomegaly (USG) in 50, hepatosplenomegaly (USG) in 40. Among the 150 cases examined, 83% experienced defervescence within 7 days, while the remaining 17% achieved defervescence by the 12th day. Ceftriaxone alone was effective in 57% of the cases, whereas the other 43% required the addition of ciprofloxacin. Conclusion: This study highlights the diverse manifestations of typhoid fever in children and emphasizes the need for prompt diagnosis and effective treatment. As antibiotic resistance continues to rise, staying informed about current drug sensitivity patterns is essential for managing typhoid fever. Ongoing initiatives in public health education and vaccination, are vital to lower the incidence of this potentially life-threatening infection in children