Background: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired insulin secretion. Inflammation plays a pivotal role in the pathogenesis of T2DM and its complications. Neutrophil-Lymphocyte Ratio (NLR) and Monocyte-Lymphocyte Ratio (MLR) are emerging as novel inflammatory markers. This study aims to evaluate the relationship between HbA1c levels and inflammatory markers NLR and MLR in controlled and uncontrolled T2DM patients. Methods: A hospital-based observational cross-sectional study was conducted on 200 T2DM patients aged 18-70 years. Participants were categorized into controlled (HbA1c <7%) and uncontrolled (HbA1c ≥7%) groups based on ADA criteria. Hematological indices including NLR and MLR were measured. Statistical analysis was performed using SPSS Version 22, with a significance level set at p<0.05. Results: The mean age was comparable between controlled (54.10±9.56 years) and uncontrolled (55.30±9.86 years) groups. NLR >2 was observed in 40.48% of controlled and 63.29% of uncontrolled diabetics (p=0.013). Similarly, MLR >2 was found in 35.71% of controlled and 61.39% of uncontrolled diabetics (p=0.005). Significant differences were noted in hematocrit values and red cell distribution width between the two groups (p<0.001). Conclusion: Elevated NLR and MLR are significantly associated with higher HbA1c levels in T2DM patients, indicating poor glycemic control. These inexpensive and readily available markers can aid in early identification of inflammation in uncontrolled diabetics, potentially guiding therapeutic interventions.