Background- Fistula in the perianal region is a tract present in between superficially on the skin around the anus and deeply in the anal canal or rectum and this tract is lined by granulation tissue. In majority of Fistula-In-Ano cases fistulotomy is done but in cases of complex fistulas, fistulotomy is not recommended as due to increase risk of re-occurrence and incontinence. One of the popular sphincter sparing method is LIFT (ligation of intersphincteric fistulous tract).The present study was done to compare the efficacy of open fistulotomy and ligation of intersphincteric fistula tract (LIFT) procedure based on its post-operative outcomes. Method- An comparative study that was done by the Surgery Department clinic at National Institute of Medical Science Research and Hospital, Jaipur between June 2022 to November 2023.Randomized sampling was done by box and chit method and the patients were allocated to one of two study groups i.e.Group A- Ligation of Intersphentric Fistulous Tract (LIFT) and Group B- Fistulotomy. Patients were operated according the group allotted. Results- The maximum patients from the age group of 25-55 years in both the groups. The male category in both the groups were highest. The mean postoperative pain andthe mean duration of hospital stay was significantly higher in Group B. The healing rate was faster (< 25 days) in Group A and recurrence was less. Conclusion- Postoperative morbidity assessed in terms post-operative pain, postoperative pus discharge, postoperative bleeding, recurrence and healing was better inpatients who undergo LIFT and was statistically significant.