Background: Diabetes mellitus (DM) is a group of common metabolic diseases that all cause hyperglycemias and are caused by different pathogenic processes. The present study was conducted to assess drug utilization among diabetes mellitus patients. Materials &Methods: 86 type II diabetes mellitus patients of both genders were selected. All were subjected to measurement of fasting, random blood glucose level. Glycated hemoglobin was also estimated.No. of drugs used and treatment adherence among patients was recorded. Results: Out of 86 patients, 50 were males and 36 were females. Single drug was used in 45, two drugs in 25 and more than 2 drugs in 16 cases. The difference was significant (P< 0.05). Treatment adherence (%) response was never, sometimes, often and always towards forgetting to take medicine in 65, 32, 1 and 2 respectively. Missing medicine when felt better was seen in 57, 39, 3and 1. Stopping medication due to sick effect seen in 58, 35, 5 and 2. Not taking medicine as stock out at home seen in 70, 23, 2 and 5. Deciding not to take medicine in 67, 23, 6 and 4. Deciding to take less medicine in 71, 20, 4 and 5. Forgetting to take drug during travel in 59, 35, 0 and 6 patients respectively. The difference was significant (P< 0.05). Conclusion: Adequate number of participants adhered to their drug regimen.