Background:The thyroid hormones play a crucial role in regulating metabolism, growth, and various other physiological processes. The presence of goitrous thyroid lesions is hypothesized to act as a precursor to thyroid carcinoma, particularly in regions where endemic goiter poses a substantial health issue. Hence, under the light of the above-mentioned data, the present was undertaken to evaluate cyto-histopathological correlation in thyroid lesions at a tertiary care centre.Materials &Methods:Total sample size for the present study included 100 patients.All patients underwent a comprehensive clinical examination in accordance with the established proforma, which included a meticulous palpation of the thyroid to accurately determine the site for aspiration. The procedure was thoroughly explained to each patient. Aspiration was conducted with the patient in a comfortable supine position, with the neck extended using a pillow placed under the shoulder to enhance the visibility of the thyroid swelling. Fine-needle aspiration cytology (FNAC) was performed under strict aseptic conditions, utilizing a 23-gauge needle along with disposable 5ml or 10ml syringes. In cases where it was deemed necessary, ultrasound-guided FNAC was employed. Smears were prepared, fixed in 95% ethyl alcohol, and stained with hematoxylin and eosin. The FNAC smears were meticulously analyzed and classified into non-neoplastic and neoplastic lesions.Results:A total of 100 cases were evaluated. Mean age was 45.3 years with majority proportion being males. On cytological analysis, neoplastic features were indicative in 33 percent of the patients while histopathology shows presence of neoplasm in 45 percent of the patients. Diagnostic accuracy, sensitivity and specificity of cytology for assessing thyroid lesions was 96.3 %, 95.1 % and 98.9 % respectively.Conclusion:Dysfunctions in thyroid function can also have repercussions on the nervous system, manifesting as sensations of numbness, tingling, pain, or burning in the regions affected. So early detection of thyroid lesions is necessary for reducing the morbidity associated with the disease.