Introduction: Cataract surgery is one of the most commonly performed ophthalmic procedures worldwide, aimed at restoring vision by removing the clouded natural lens and replacing it with an artificial intraocular lens (IOL). Ensuring patient comfort during cataract surgery is paramount for optimizing surgical outcomes, enhancing patient satisfaction, and minimizing intraoperative complications. Anesthesia plays a critical role in achieving this comfort, with topical anesthesia and Sub-Tenon block being widely utilized techniques. This study provides a comprehensive comparison between these two anesthesia methods in the context of cataract surgery.Objective: To compare the efficacy of topical anesthesia and Sub-Tenon block in ensuring patient comfort during cataract surgery.Methodology: A prospective, comparative study involving 175 patients undergoing cataract surgery was conducted. Participants were randomly assigned to receive either topical anesthesia or Sub-Tenon block. Comprehensive data were collected on patient comfort, pain perception, procedure duration, intraoperative complications, and overall satisfaction. The analysis aimed to determine the differences in these parameters between the two anesthesia methods.Results: Patients receiving Sub-Tenon block reported significantly lower pain scores compared to those receiving topical anesthesia. The procedure duration was slightly longer in the Sub-Tenon group, but this difference was not clinically significant. Intraoperative complications were minimal and comparable between the two groups. Overall patient satisfaction was notably higher in the Sub-Tenon block group.Conclusion: Sub-Tenon block anesthesia provides superior patient comfort and satisfaction during cataract surgery compared to topical anesthesia. Despite a marginal increase in procedure time, the benefits in pain management and reduced patient movement make Sub-Tenon block a preferable choice for anesthesia in cataract surgeries.