Objective: The study aimed to evaluate the impact of advanced anesthetic techniques on the outcomes of retinal and corneal surgeries, focusing on patient comfort, surgical duration, postoperative pain, and overall patient satisfaction. Methodology: A descriptive, observational design was employed to analyse the effects of advanced anesthetic techniques, including intracameral agents, Sub-Tenon’s block, and topical anesthesia, on patients undergoing retinal and corneal surgeries at a tertiary care ophthalmology center. A total of 150 patients, aged 18 to 75 years, were selected using stratified random sampling. Data were collected through patient records, surgical outcomes, and anesthesia protocols, as well as through patient satisfaction surveys and interviews with ophthalmic surgeons and anesthesiologists. Results: The study found that intracameral agents resulted in the shortest surgical duration, the lowest postoperative pain, and the highest levels of patient satisfaction. Sub-Tenon’s block provided effective pain management but was associated with a longer recovery time. Topical anesthesia, while reducing surgical time, was linked to slightly higher postoperative pain and lower satisfaction compared to the other techniques. The statistical analysis indicated that intracameral agents were significantly more effective in improving patient outcomes, with a p-value of <0.05. Conclusion: The study concluded that advanced anesthetic techniques, particularly intracameral agents, significantly enhanced the outcomes of retinal and corneal surgeries by reducing pain, shortening recovery times, and improving patient satisfaction. Sub-Tenon’s block remains a viable option for longer procedures, while topical anesthesia is best suited for less invasive surgeries. These findings contribute to the growing body of evidence supporting the adoption of modern anesthetic practices in ophthalmology, ultimately improving surgical care and patient outcomes.