Background: Elevated serum uric acid (SUA) has been linked to hypertension (HTN) through various mechanisms. This study aimed to assess SUA levels in patients with essential HTN and to explore their association with age, sex, body mass index (BMI), smoking, diabetes, and target organ damage. Methods: A hospital-based case-control study was conducted at Ramkrishna Care Hospital, Raipur, from May 2021 to March 2022. The patients aged 25 years and older diagnosed with essential HTN of both sexes were included with the written informed consent. Data collection involved medical history, physical examination, fasting serum uric acid levels, a blood haemogram,blood urea and serum creatininetests, blood pressure measurement, and BMI. Results: A total of 100 patients were included, with 32 cases and 68 controls. The mean (SD) age of cases was 56.25 (10.9) years, while control group had 52.4 (11.53) years. Significant differences in blood pressure (BP) were observed, with mean systolic BP of 165.13 mmHg in cases vs. 122.29 mmHg in controls (P<0.001) and mean diastolic BP of 103.94 mmHg in cases vs. 77.74 mmHg in controls (P<0.001). A significant difference was observed in mean urea levels, with cases having 31.38 (6.37) mg/dL and controls with 28.07 (5.43) mg/dL.The mean (SD) serum creatinine levels were elevated in cases [1.01 (0.28 mg/dL)] compared to controls [0.88 (0.16 mg/dL), P<0.001].The SUA levels were significantly higher in cases (6.33 mg/dL) compared to controls (5.01 mg/dL, P<0.001). Conclusion: Elevated SUA levels are significantly associated with essential HTN, with higher SUA levels observed in patients with HTN compared to controls.