Diabetic retinopathy and macular lump are complicated diseases. VEGF plays an important role in the pathological process of non-chronic diabetic macular lump, and VEGF blockade agents can improve vision. In chronic diabetic macular lump, inflammatory cy- tokines are the main driver of lump, and intravitreal steroids can lead to lump resolution. However, vascular part isn’t always the cause of macular thickening and visual loss from non-vascular parts.