Background: Root canal therapy (RCT) is a cornerstone of endodontic treatment, aiming to eradicate infection, seal the root canal system, and restore tooth functionality. Sealers play a critical role in achieving these goals by filling voids, adhering to canal walls, and preventing microbial leakage. While traditional sealers, including zinc oxide-eugenol and resin-based formulations, have been widely used, bioceramic sealers have emerged as a promising alternative due to their biocompatibility, superior sealing properties, and bioactivity. Aim: This study aims to compare the clinical efficacy of bioceramic sealers versus traditional sealers in root canal treatment outcomes, focusing on factors such as post-treatment pain, healing rates, and long-term success. Methods: A prospective clinical study was conducted on 100 patients requiring root canal therapy. Participants were randomly assigned to two groups: one receiving bioceramic sealer and the other a traditional sealer (zinc oxide-eugenol or resin-based). Baseline clinical and radiographic evaluations were performed before treatment. Postoperative assessments were conducted at intervals of 1 week, 3 months, and 6 months, evaluating pain levels (VAS scale), periapical healing (PAI scores), and treatment success. Statistical analysis was conducted to compare outcomes between the two groups, with a significance level set at p < 0.05. Result: Patients treated with bioceramic sealers reported significantly lower postoperative pain scores (mean VAS: 2.1 ± 0.9) compared to the traditional sealer group (mean VAS: 3.5 ± 1.2; p < 0.01). Radiographic evaluations demonstrated faster and more complete periapical healing in the bioceramic group, with 82% achieving optimal healing by 6 months, compared to 65% in the traditional group (p < 0.05). Treatment success rates were higher for bioceramic sealers (90%) than traditional sealers (75%). Conclusion: Bioceramic sealers outperform traditional sealers in root canal therapy, offering superior postoperative pain relief, enhanced periapical healing, and higher overall success rates. These findings support the adoption of bioceramic sealers as a preferred material in modern endodontics. Future studies should explore long-term outcomes and cost-effectiveness to further validate their clinical utility.