Background: A situation that interferes with a person's regular psychological or physiological functioning is referred to as stress. The present study was conducted to assess effects of Yoga in patients with type 2 diabetes mellitus and hypertension. Materials &Methods: 58 patients of type 2 diabetes along with hypertension of both gendersreceived yoga therapy for 45 days along with the standard treatment. Oxidative stress markers such as changes in RBC morphology (crenated edges and Heinz bodies), malondialdehyde levels along with fasting blood glucose levels, systolic & diastolic blood pressure, body mass index and symptoms associated with type 2 diabetes were evaluated before and at the end of the yoga therapy. Results: Out of 58 patients, 30 were males and 28 were females. Before and after yoga therapy BMI found to be 23.6 and 22.1, Malondialdehyde was 65.3 µM/L and 46.2 µM/L, glucose level was 210.5 mg/dl and 132.8 mg/dl, SBP was 142.6 mm Hg and 132.4 mm Hg and DBP was 84.2 mmHg and 80.6 mm Hg. The difference was significant (P< 0.05). There was significant change in the severity ranking of the RBC Morphology before and after Yoga therapy (P< 0.05). Conclusion: Frequent yoga practice helps to improve blood pressure, body mass index, glycemic parameter, and RBC shape by reducing oxidative stress-induced damage. It may also reduce the risk of illness complications.