Background & Aim: Apicectomy is the surgical removal of the apical portion of the tooth and the attached soft tissues during periapical surgery. Presence and absence of Root-End Filling material have their own effects on the overall efficiency of apicoectomy procedure. This study was aimed to evaluate the efficacy of apicoectomy procedure performed with or without root-end filling. Materials and Methods: In this clinical study, both male and female patients were selected for planned evaluations. All 40 patients were studied into 2 major groups. Group 1 has 20 patients wherein apicoectomy procedure was attempted with root-end filling materials (MTA: Mineral Trioxide Aggregate). Group 2 has 20 patients wherein apicoectomy procedure was attempted without root-end filling materials. Written and signed informed consent was obtained from all patients. Patient called after twelve days for surgical follow up. Satisfactory, Non-satisfactory and Questionable responses were seen and assessed after 2 months and 4 months timings post operative timings. Results thus obtained was compiled and sent for basic statistical analysis. P value less than 0.05 was considered as significant (p< 0.05). Statistical Analysis and Results: 15 patients were noticed in the age range of 24-25 years. P value was highly significant here (0.02). 5 patients were found in the age of 30 years. Total 23 male and 17 female patients were studied particularly. For Group 1, 17 patients were satisfied as and P value was highly significant here (0.01). Only 2 patients were not satisfied and 1 patient showed questionable response. For Group 1 noted after 4 months, 16 patients were satisfied as and P value was not significant here (0.17). Only 3 patients were not satisfied. The evaluation amongst all 2 Groups using one-way ANOVA showed highly significant difference and p value (0.001). Conclusion: Within the limitations of the study authors have concluded that apicoectomy procedure is a feasible option and offer patient satisfaction. In this study, high therapeutic satisfaction was identified in the patients of apicoectomy with root-end filling. This was observed in both of the tested post operative follow up timings. Patients with Apicoectomy without root-end filling expressed lower level of therapeutic satisfaction in both of the tested post operative follow up timings.