Background: One serious side effect of diabetes is diabetic plantar ulcers, which often result in a longer healing period and a higher risk of infection. For wound healing, vacuum-assisted closure (VAC) treatment has shown promise as a substitute for traditional debridement. This research examines how well VAC treatment and traditional debridement work to treat diabetic plantar ulcers. Materials and Methods: 60 diabetic individuals with plantar ulcers participated in a prospective trial. Two groups of thirty participants each were randomly assigned to undergo VAC treatment and traditional debridement, respectively, in Group B. Over a 12-week period, ulcer healing was evaluated using metrics such the decrease in wound size, duration to granulation, and the occurrence of complications. To ascertain the relative efficacy of the two strategies, data were examined using statistical techniques. Results: Compared to 60% in Group B (mean reduction: 45%), 80% of patients in Group A demonstrated a substantial decrease in wound size (mean reduction: 75%). In Group A, the average time to granulation was 4 weeks, whereas in Group B, it was 7 weeks. Ten percent of Group A patients had complications like infection, compared to thirty percent of Group B patients. VAC treatment significantly improved healing results, according to statistical analysis (p < 0.05). Conclusion: In the treatment of diabetic plantar ulcers, VAC therapy proved to be more successful than traditional debridement, resulting in quicker wound size reduction, earlier granulation, and fewer sequelae. According to these results, VAC treatment may be a useful strategy for treating diabetic foot ulcers.