Introduction- vascular malformations represents localized defect in morphogenesis of the vessels and composed of inappropriate vasculature connections. In slow-flow lesions, sclerotherapy, laser therapy, surgery or combination of sclerotherapy followed by surgery is considered as treatment of choice. So, purpose of this case series study is to describe our clinical experience of staged sequential sclerotherapy using 3% sodium tetradecyl sulphate in slow flow vascular malformation maxillofacial lesions. Materials and methods- Seven patients of slow-flow oral vascular malformation maxillofacial lesions were included in this case series study. 0.1 to 1 ml of STS was injected firstly at the periphery of the lesion and then towards the center of the lesion at multiple sites using insulin syringes after providing surface anesthesia with 15% xylocaine spray. Injections were repeated after interval of 2 weeks whenever required, which varied from 1 to 5 sessions according to the size of the lesion. Results- Significant results were seen within 2 weeks in the post sclerotherapy session in terms of the lesion regression and esthetic outcome thereby improving the quality of life. Conclusion- Sclerotherapy has emerged as an altervative minimally invasive procedure with a low recurrence rate, good esthetic results, and reasonable morbidity.