Background: Breast cancer is a pervasive and impactful malignancy, causing substantial global mortality. This study explores the association between ovary removal, hormone replacement therapy (HRT), and familial factors in the context of breast cancer, aiming to unravel the intricate mechanisms influencing its etiology and prognosis. Methods: This prospective study was executed at Sher-i-Kashmir Institute of Medical Sciences, Soura. Rigorous data collection employed a meticulously crafted questionnaire, validated through expert reviews and pre-testing. Data on ovary removal patterns, HRT usage, and familial breast cancer history were collected across various districts. Statistical methods were employed to determine frequencies and percentages, providing a nuanced understanding of these interrelated factors. Results: The compiled data, when considered across all districts, indicated an overall frequency of one ovary removal at 1.77%, notably contrasting with a significantly higher frequency of 98.23% for individuals who did not undergo any oophorectomy. Familial factors play a significant role, with 13.27% reporting a positive history, emphasizing the need for tailored screening. HRT usage was low (0.88%), influenced by historical events and aligned with reduced breast cancer risk post-HRT discontinuation. Conclusion: The comprehensive analysis of ovary removal patterns, familial breast cancer history, and HRT usage provided nuanced insights into breast cancer management dynamics. Oophorectomy aligns with historical trends, familial factors underscore the need for tailored strategies, and low HRT usage resonates with reduced breast cancer risk post-discontinuation. These observations contribute to a holistic understanding, guiding targeted healthcare interventions in breast cancer prevention and treatment.