Background: Gallstone-induced acute pancreatitis, a significant cause of morbidity and mortality, necessitates laparoscopic cholecystectomy to prevent recurrence. However, the optimal timing of surgery remains debated. This study compares outcomes of laparoscopic cholecystectomy during index admission versus delayed surgery. Methods: A 12-month prospective observational study at Himalayan Institute of Medical Sciences, Dehradun, included 46 patients undergoing laparoscopic cholecystectomy for gallstone pancreatitis. Patients were categorized into index admission (n=36) and delayed surgery (n=10) groups. Data on demographics, clinical presentations, surgery, complications, and outcomes were analyzed. Results: Among 46 patients (67.39% female, mostly in the 4th–5th decades), there was no significant difference in operative time (56.72 vs. 53.22 minutes) or difficulty. Delayed surgery resulted in longer hospital stays (10.44 vs. 6.48 days; p = 0.029) and higher unplanned readmissions (40%). Post-operative complications were minimal, with no bile duct injuries or retained CBD stones. Conclusion: Index admission laparoscopic cholecystectomy is safe, reduces hospital stays, and lowers recurrent biliary events, supporting its preference over delayed surgery.