Background: Breast cancer remains the foremost cause of cancer-related fatalities among women globally. Although mammography has traditionally been regarded as the gold standard for screening and early detection, its implementation is often impractical in resource-constrained environments. This challenge arises from the substantial costs associated with acquiring and maintaining the necessary equipment, as well as the difficulties in training and retaining qualified technologists and radiologists for image interpretation. Hence, the present study was conducted for comparative analysis of accuracy of mammography and ultrasound in women with breast symptoms. Materials & Methods: The study involving 100 women presenting with breast symptoms was conducted. Breast lesions were identified through clinical breast examination, mammography, and ultrasound imaging. All detected lesions underwent histological analysis. The histopathological findings indicated the presence of 42 cases of malignant and 58 benign lesions. A comprehensive medical history was obtained from each participant. The diagnostic protocol included clinical breast examination, ultrasound, mammography, and histopathological evaluation. The clinical breast examination was carried out on the entire breast and axillary regions while the patient was seated, with arms positioned both at rest and elevated. All the results were recorded and analyzed using SPSS software. Results: A total of 100 subjects were evaluated. The mean age of the subjects was 35.3 years. Among these 100 subjects, malignant lesions were seen in 42 percent of the patients while the remaining 58 percent of the patients showed benign lesions. Ultrasound was superior to mammography in detection of both benign and malignant lesions. Conclusion: Breast ultrasound is more accurate than mammography in symptomatic women.