Background: Mammography has emerged as a standard screening method for breast cancer. MRI serves as an adjunctive diagnostic modality to mammography and ultrasound in the assessment of breast cancer, particularly in younger women with dense breast tissue. Hence; the present study was conducted for evaluation of role of diffusion weighted MRI imaging in assessment of nuclear grade of breast carcinoma at a tertiary care hospital. Materials & Methods: 40 patients with histopathologically proven breast carcinoma were included. MRI examinations were performed within 2 weeks before surgery. All patients were scanned. Prior to the administration of contrast media, axial bilateral fat-suppressed T2-weighted fast spin-echo and diffusion-weighted imaging (DWI) series were obtained. The ADC values of the lesions were measured. All 40 participants who underwent breast MRI subsequently had surgical intervention. Histopathological and immunohistochemical analyses of the surgical specimens were conducted to identify prognostic factors. All the results were recorded in Microsoft excel sheet and were subjected to statistical analysis using SPSS software. Results: Restricted diffusion on DWI was seen in all the patients. 62.5 percent of the patients were of T2 stage of TNM staging. In ROC curve analysis in which grade I was compared with grade II and III, the minimum ADC cut-off value was calculated as 0.77 × 10-3 mm2/sec with 87% sensitivity and 82% specificity. Significant results were obtained while correlating ADC values with tumor grading. Conclusion:MRI studies employing DWI are capable of detecting the biological heterogeneity present within tumor tissue, with ADC values exhibiting considerable variation based on the biological characteristics of breast cancer.