Objective: This study aimed to explore the impact of acne severity on the quality of life among adolescents, examining physical, emotional, and social well-being. Methodology: A cross-sectional design was employed, with 350 adolescents aged 13–19 years, recruited from local clinics. The inclusion criteria required participants to have been diagnosed with acne, while those with other dermatological conditions or systemic illnesses were excluded. Data collection was conducted through structured interviews and standardized questionnaires assessing acne severity and quality of life. The Acne Severity Indexwas used to classify acne severity, and the Quality of Life in Acnescale assessed various domains of well-being. Descriptive statistics, regression analysis, and chi-square tests were applied to analyze the data. Result: The findings revealed a significant negative relationship between acne severity and quality of life. Adolescents with severe acne reported the lowest scores across all domains i.e., physical, emotional, and socialcompared to those with mild or moderate acne. Gender differences were also noted, with females experiencing a greater decline in quality of life than males. Socioeconomic status was another influencing factor, with lower-income adolescents reporting greater challenges in managing acne and accessing treatment. Furthermore, the most common barriers to treatment included financial constraints, lack of awareness, and fear of stigma. Conclusion: Acne severity was found to significantly affect adolescents' quality of life, with severe acne being associated with the most profound impact. Gender and socioeconomic disparities exacerbated the psychosocial consequences, emphasizing the need for targeted interventions. The study highlights the importance of addressing both the physical and emotional aspects of acne treatment, advocating for improved access to care and public health initiatives to reduce stigma and raise awareness.