Introduction: Blood pressure is the lateral pressure exerted by circulating blood against the walls of the blood. Blood pressure can be measures using different methods, however, the gold standard being the Auscultatory method.(1) Pulse oximeter is a device used for monitoring pulse rate and saturation.(2) Peripheral vascular disease (PVD) is a key reason for mortality and morbidity(3).It is usually diagnosed with Anke Brachial Index(ABI) by Doppler but is expensive and not easily available. Pulse oximetry was the method used to record the blood pressure of the patients in the present study. Hence the present study was done to study the validity of Pulse oximetry wave pattern appearance in the measurement of systolic blood pressure by comparing it with Auscultatory (conventional) method of blood pressure recording in individuals.2. To study the validity of systolic blood pressure for Ankle Brachial Index using pulse oximetry waveform pattern appearance by comparing it with Doppler (conventional) method in Peripheral Vascular Diseases.3. To measure systolic blood pressure using pulse oximetry in Takayasu Arteritis cases. Methodology: A cross- sectional analytical study was conducted in Kasturba Medical College, Mangalore from September 2019 to September 2021 among patients attending general OPD and Peripheral Vascular Disease population and Takayasu Arteritis cases. Results:183 individuals in General population met the inclusion criteria and systolic blood pressure measured using auscultatory and pulse oximetry method was compared and results showed statistical significance between both the methods with p value < 0.05 and Intraclass Correlation Coefficient > 0.9. ABI measured in 60 PVD population using Doppler and pulse oximetry method when compared also showed statistical significance. 4 Takayasu Arteritis cases showed higher BP recordings when measured using pulse oximetry as compared to Doppler method. Conclusion: Through this study we conclude that Pulseoximetry reappearance of waveform method is accurate and feasible to measure the Systolic Blood Pressure. Pulse oximetry can also be used in Peripheral Vascular Disease patients, where Doppler might not be easily available. We also conclude that, Pulse Oximetry method of BP measurement can be used in Takayasu Arteritis cases, where SBP can be measured even when conventional methods fail to record Blood Pressure.