Background:For improved management, outcome prediction is crucial in both clinical and administrative intensive care units (ICUs). The present study assessed SOFA score to predicting outcome in critically ill patients. Materials & Methods:95 critically ill patients of both genders were enrolled. At the time of admission and every 48 hours until release, the SOFA score was recorded. The lowest values for each parameter over the 24-hour period were used to calculate the score. Results:Out of 95 patients, 52 were males and 43 were females. Type of admission was medical in 60 and surgical in 35. The difference was significant (P< 0.05). The mean SOFA score correlated most closely with mortality followed by the highest score and the initial score (P< 0.01). Conclusion:For critically ill patients in intensive care units, the mean and highest SOFA values are especially helpful indicators of outcome.