Background: Psychoactive substance use is a significant concern in professions demanding high levels of vigilance and responsibility. Security guards, due to their stressful work environment and irregular schedules, may be particularly vulnerable. This study investigates the prevalence, patterns, and occupational impacts of substance use among security guards.Objective: To determine the prevalence of psychoactive substance use among security guards, identify contributing factors, and assess the occupational and health-related impacts of such behaviors.Methods: A cross-sectional study was conducted among 85 security guards, selected using purposive sampling. Data were collected using structured questionnaires and interviews focusing on demographic characteristics, substance use patterns, occupational factors, and health impacts. Quantitative data were analyzed using descriptive and inferential statistics.Results: The study found that 58% of participants reported psychoactive substance use, with alcohol (40%) and tobacco (35%) being the most common substances. Stress relief (45%), fatigue management (25%), and social influence (20%) were the primary reasons for use. Occupational impacts included impaired performance (30%), accidents (12%), and absenteeism (20%). Health effects included anxiety (25%) and fatigue (18%). Additionally, 60% of participants reported the absence of workplace substance use policies, and 70% expressed interest in counseling or support programs.Conclusion: The prevalence of psychoactive substance use among security guards is high, driven by occupational stress, fatigue, and workplace culture. These behaviors have significant implications for job performance and health. The findings underscore the need for workplace interventions, including stress management programs, clear substance use policies, and access to mental health support.