Introduction: Accurate diagnosis of the cause is crucial in the management of obstructive jaundice. Multidetector computed tomography (MDCT) play the pivotal role in the diagnosis. Study was planned to evaluate the usefulness of multiphasic MDCT in detection and characterization of the cause of obstructive jaundice and to provide information on the cause and make diagnosis that help clinician to determine the choice of treatment. Methods: This hospital based observational study included 50 patients who were referred to the Department of Radiodiagnosis & Imaging with clinical features of obstructive jaundice. The USG and MDCT evaluation of cases with obstructive jaundice were performed and diagnostic efficacy of USG versus MDCT was analysed. Results: Diagnostic accuracy of USG was compared to MDCT and we found sensitivity was 44.5%, specificity was 52.2% and accuracy was 46.9%. According to MDCT diagnosis, maximum number of patients had CBD stricture (22%). Conclusion: Ultrasound as a initial screening modality is useful to diagnose or exclude biliary obstruction. The MDCT could serve as better, superior initial, cost-effective, widely available, and time efficient imaging modality for diagnosing various causes of obstructive jaundice.