Background: Postoperative pain causes increased morbidity and longer hospital stay and is most common complaint after open cholecystectomy. Perioperative infusion of dexmedetomidine and lidocaine decrease perioperative requirements for analgesics. The aim of the study is to compare the effects of intraoperative infusion of lidocaine and dexmedetomidine on postoperative analgesia after open cholecystectomy. Materials and Methods: Double blind , randomized controlled study on eighty patients of both sex between 20-60 years, posted for elective open cholecystectomy were randomly assigned to two groups (n=40 each). The patients in group D received intravenous bolus of dexmedetomidine 1µg/kg followed by continuous infusion of 0.4µg/kg/h. The patients in group L received intravenous bolus of lidocaine 1.5mg/kg followed by continuous infusion of 2mg/kg/h. Bolus doses were given 10 minutes before induction of anaesthesia , followed by infusions which were stopped after last skin suture.Hemodynamic changes monitored changes and sedation score were evaluated in perioperative period. Visual analogue scale (VAS) score, total postoperative analgesic consumption were evaluated till 24 hours after surgery. Statistical analysis was analyzed using SPSS software version 15.0, Chi-square test was used for qualitative data. ANOVA and unpaired t test were used for continuous variables. P value of <0.05 was considered as significant. Result: Dexmedetomidine had better postoperative analgesia, less VAS score (<4), and total postoperative analgesic consumption when compared to lidocaine (p<0.05). Conclusion: Both dexmedetomidine and lidocaine were effective for controlling postoperative pain, hemodynamic stabilization, but dexmedetomidine had a better analgesic profile. Hence, Dexmedetomidine administered at bolus dose of 1µg/kg followed by infusion of 0.4µg/kg/h serve as an anaesthetic adjuvant of choice in patients undergoing elective open cholecystectomy.