Background-Supraclavicular brachial plexus block (SCB) is a commonly used regional anesthesia technique for upper limb surgeries, providing effective analgesia with fewer systemic complications compared to general anesthesia. Aims-This study aims to compare the efficacy, onset, duration of action, and safety profile of levobupivacaine alone versus levobupivacaine combined with dexmedetomidine for supraclavicular brachial plexus block in patients undergoing upper limb surgeries. Method-A double-blind, randomized controlled trial was conducted with 60 patients divided into two groups. Group A (n=30): 29 ml of 0.5% Levobupivacaine + 1ml Normal saline Group B (n=30): 29 ml of 0.5% Levobupivacaine + 1ml (100 microgram) Dexmedetomidine. The primary endpoints included sensory and motor block onset times, block duration, and the need for rescue analgesia. Secondary endpoints assessed hemodynamic stability, adverse effects. Results-Results showed that the combination of levobupivacaine with dexmedetomidine significantly reduced the onset time of both sensory and motor blocks compared to levobupivacaine alone. The block duration was prolonged in the levobupivacaine-dexmedetomidine group, with a longer analgesic effect and reduced requirement for postoperative analgesia. Hemodynamic parameters were stable in both groups, with no significant differences in side effects. Conclusion-The combination of dexmedetomidine with levobupivacaine provided superior analgesia, faster onset, and extended block duration, while maintaining a comparable safety profile. This study supports the use of levobupivacaine with dexmedetomidine as an effective and safe alternative for supraclavicular brachial plexus blocks.