Abstract Issue

Volume 13 Issue 12 (December) 2024

Original Articles

Evaluating Biochemical Changes in Liver Function Tests in Liver diseases
Dr. Bhavinkumar Rameshkumar Mevada, Dr. Jignesh Maganlal Solanki, Dr. K. Swetha, Dr. D. Vennela

Background: Liver diseases in India have experienced a marked increase due to multiple contributing factors, including viral hepatitis, alcohol-induced liver damage, non-alcoholic fatty liver disease, and various metabolic and genetic conditions. Liver function tests (LFTs) are essential diagnostic tools for clinicians, providing critical information about the intricate relationship between liver health and disease pathology. This study aimed to comprehensively analyze the changes in LFT parameters associated with common liver disorders prevalent in India. Materials and Methods: This research involved collecting clinical data and samples from 145 patients diagnosed with liver diseases who attended an Indian hospital. Written informed consent was secured from all participants. Venous blood was drawn from each participant following standard venipuncture technique. Hepatitis B surface antigen (HBsAg), Bilirubin levels, Serum glutamate pyruvate transaminase (SGPT), Prothrombin time, Serum protein and albumin-to-globulin (AG) ratio were measured using a combination of fully and semi-automated analyzers. Results: The study revealed a 15.86% prevalence of cirrhosis among the participants. Liver diseases were more commonly observed in males, with the most affected age group being 51–60 years. Bilirubin levels were notably altered in conditions such as cirrhosis (73.91%), obstructive jaundice (91.43%), alcoholic liver disease (93.10%), viral hepatitis (75.86%), and other liver disorders (86.21%). Conclusion: Changes in LFT parameters are instrumental in identifying the underlying causes of liver diseases. Specific alterations in liver enzymes and HBsAg reactivity were particularly significant in diagnosing cirrhosis and viral hepatitis.

 
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