Abstract Issue

Volume 13 Issue 11 (November) 2024

Original Articles

Study of diastolic dysfunction in newly detected cases of type 2 diabetes mellitus and its correlation with HbA1c
Dr. R.M.Honntagi, Dr. Chaitanya C. Patil, Dr. Deepak Chinagi, Dr. Vinod Kumar Reddy

Background: Diastolic abnormalities pertaining to the left side of ventricle imply the early categorization of heart disorders related to Diabetes, including Diabetic Cardiomyopathy. The diastolic abnormalities occur before the systolic abnormalities, and echocardiography is critical in the early determination of diastolic abnormalities. A cross-sectional study, aiming to understand the incidence of diastolic dysfunction among cases of diabetes mellitus in the first three months of their diagnosis and to correlate diastolic dysfunction and values of HbA1c. Materials and Methods: The study in Vijayapura in Karnataka had 63 patients with recently detected Diabetes Mellitus. Individuals with severe anemia, hemoglobinopathies, renal failure, valvular, ischaemic, and hypertensive cardiac disease, and patients with diagnosed Diabetes on medications were not included. The patients who were included gave their consent. In order to evaluate further, postprandial blood sugars, fasting blood samples, and HbA1c were obtained. Echocardiography was also performed to assess diastolic dysfunction. A statistical analysis was conducted utilising the Mann-Whitney and Chi-square tests. Results: Thirty-seven male and twenty-six female patients made up the 63 participants in the study. 49.2% of people had diastolic dysfunction. In patients with HbA1c of more than 8, 51.6% had diastolic dysfunction and 62.5% did not have diastolic dysfunction. p value was 0.383. Patients with diastolic dysfunction had mean fasting blood sugar levels of 169.65 mg/dl, while those without diastolic dysfunction had mean levels of 162.75 mg/dl. The p-value was 0.842. Patients with diastolic failure had mean postprandial blood sugars of 206, whereas patients without diastolic dysfunction had mean blood sugars of 223. p value was 0.251.Eight individuals with left ventricular hypertrophy had diastolic dysfunction. Albuminuria was present in 24 individuals with diastolic dysfunction.p value was 0.193. Conclusion: Diastolic abnormalities of the left ventricle are the first hallmark of diabetic Cardiomyopathy, and the degree is correlated with HbA1c levels. Diastolic dysfunction in diabetic patients leads to relatively early onset of congestive heart failure.Pulsed wave Doppler echocardiography can detect diastolic dysfunction early in the course of the illness.

 
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