Aim: This study aimed to compare the effects of general, regional, and combined anesthesia protocols on post-surgical recovery outcomes in patients undergoing elective surgeries. Material and Methods: A prospective, randomized, controlled study was conducted with 150 patients aged 18–65 years undergoing elective surgeries. Participants were randomized into three groups: General anesthesia (Group G, n=50), Regional anesthesia (Group R, n=50), and Combined general and regional anesthesia (Group C, n=50). Data collected included demographics, intra-operative parameters, recovery times, post-operative pain scores (VAS), opioid consumption, and complications. Statistical analysis was performed using ANOVA, Chi-square tests, and p-values <0.05 were considered significant. Results: The groups were comparable in baseline characteristics (p > 0.05). The Regional group had the shortest recovery time (145 ± 20 minutes), followed by the Combined group (160 ± 22 minutes), and the General group (180 ± 25 minutes; p < 0.001). Pain scores at 6, 12, and 24 hours were significantly lower in the Regional group, followed by the Combined and General groups (p < 0.001). Opioid consumption and hospital stays were also lowest in the Regional group, followed by the Combined and General groups (p < 0.001 and p < 0.05, respectively). Post-operative complications, including nausea and vomiting, were least common in the Regional group (p = 0.02). Conclusion: Regional anesthesia demonstrated superior outcomes, including shorter recovery times, better pain control, and fewer complications. Combined anesthesia offered intermediate benefits, while general anesthesia was associated with longer recovery times and higher opioid use. Tailoring anesthesia protocols based on patient and surgical needs can optimize recovery outcomes.