Background:Occupational contact dermatitis (OCD) is a prevalent work-related skin condition, particularly among healthcare workers (HCWs) due to frequent exposure to irritants and allergens.Objectives:To determine the prevalence of OCD among HCWs, identify key risk factors, and evaluate the effectiveness of current preventive practices.Methods:A cross-sectional study was conducted with 320 HCWs from various healthcare facilities. Data were collected using structured questionnaires and dermatological assessments. Statistical analysis was performed to identify significant associations between OCD and risk factors.Results:The incidence of OCD was 30%, with irritant contact dermatitis (ICD) accounting for 75% of cases and allergic contact dermatitis (ACD) for 25%. Frequent handwashing (≥10 times/day), prolonged glove use (>4 hours/day), and a history of atopic dermatitis were significantly associated with OCD (p < 0.05). Only 30% of affected HCWs reported using emollients regularly, and 40% received formal training on skin care.Conclusions:It is concluded that OCD is a common occupational hazard among HCWs, with significant impacts on their well-being and job performance. Enhanced preventive measures, including skin-friendly hygiene practices, hypoallergenic gloves, and comprehensive education programs, are essential to reduce its incidence.