Background:Chronic Kidney Disease (CKD) is associated with a wide range of dermatological manifestations that significantly impact patients’ quality of life. Despite their prevalence, these manifestations are often overlooked in clinical practice. Objective:This study aimed to evaluate the prevalence of skin changes in CKD patients and their impact on daily life.Methods:A descriptive cross-sectional study was conducted among 320 CKD patients at a tertiary care hospital. Participants were selected based on inclusion criteria, including confirmed CKD diagnosis and the ability to provide informed consent. Data were collected using a standardized questionnaire covering demographic details, CKD stage, and dermatological manifestations, including xerosis, pruritus, hyperpigmentation, hair, and nail changes. Statistical analysis was performed using SPSS v20.0, with a p-value <0.05 considered significant.Results:The study population consisted of 60% males and 40% females, with a mean age of 52.3 years. Xerosis was the most prevalent dermatological manifestation, affecting 62% of participants, followed by pruritus (54%), hyperpigmentation (40%), and nail changes (52%). Nail abnormalities included Lindsay's nails (34%), Beau's lines (15%), and koilonychia (3%). The prevalence of symptoms increased with CKD severity, with Stage 5 patients showing the highest rates of xerosis (75%), pruritus (70%), and nail changes (68%). Dermatological symptoms affected daily life, with 38% reporting mild impact, 30% moderate impact, and 10% severe impact.Conclusion:Dermatological manifestations are highly prevalent among CKD patients and have a significant impact on their quality of life. The findings emphasize the need for regular dermatological assessments and targeted management as part of comprehensive CKD care. Future studies should explore interventions to mitigate these symptoms and improve patient outcomes.