Background:Laparoscopic cholecystectomy, including single-incision laparoscopic cholecystectomy (SILS), is a widely performed minimally invasive procedure for gallbladder diseases. SILS offers potential benefits but faces adoption challenges due to technical and ergonomic limitations.Objective:To evaluate the outcomes and challenges associated with laparoscopic cholecystectomy, focusing on SILS, based on demographic trends, preoperative evaluations, intraoperative details, and postoperative outcomes.Methods:A retrospective analysis was conducted on 105 patients who underwent laparoscopic. Data on demographic characteristics, preoperative imaging and laboratory findings, surgical techniques, intraoperative complications, and postoperative recovery were collected and analyzed using SPSS v26.Results:The mean age of patients was 45.21 ± 9.87 years, with a female predominance (66.7%). The most common comorbidity was hypertension (23.8%). Symptomatic gallstone disease accounted for 85.7% of cases, and ultrasound was used in all preoperative evaluations. SILS was performed in 14.3% of cases, with a mean operative time of 60 ± 15 minutes. Complications were infrequent, including intraoperative bleeding (4.8%) and bile duct injuries (2.4%). Postoperative outcomes showed a mean hospital stay of 2.3 ± 1.5 days, with low complication rates, including wound infections (2.4%).Conclusion:Laparoscopic cholecystectomy is a safe, effective procedure with low complication rates and rapid recovery. SILS demonstrates potential advantages in selected cases but requires further advancements in instrumentation and training to overcome its technical challenges and expand its clinical utility.