Background: Males who have benign prostatic hyperplasia (BPH), a common chronic condition that progresses slowly, have an enlarged prostate gland and a blocked bladder outlet. The present study was conducted to compare intrathecal dexmedetomidine with low-dose bupivacaine spinal anaesthesia and a higher dose of bupivacaine in patients undergoing TURP. Materials & Methods: 80 adult males aged 40- 70 years with benign prostate hyperplasia undergoing TURPwere divided into 2 groups of 40 each. In group I, patients received 7.5 mg of 0.5% hyperbaric bupivacaine hydrochloride and group II patients received 3 µg of dexmedetomidine hydrochloride combined with 6 mg of 0.5% hyperbaric bupivacaine hydrochloride. Regression time from peak sensory block level, VAS (hours), the Modified Bromage score at the conclusion of operation, the need for analgesics during and after surgery, and adverse effects were among the parameters that were noted. Results: The time to reach T10 sensory block was 12.1 in group I and 10.4 in group II. VAS score at 1 hour was 2.7 and 1.3, 2 hours was 3.4 and 2.9, 3 hours was 2.7 and 1.8 and 4 hours was 1.2 and 1.9. Modified Bromage score at the end of surgery 1 was seen in 1 in group I, 2 in 5 in group I and 15 in group II, 3 seen 342 in group I and 25 in group II. The difference was significant (P< 0.05). Side effects were vomiting 5 in group I and 8 in group II, nausea seen in 3 in group I and 1 in group II, pruritus 2 in group I and 4 in group II and hypotension 1 in group I and 2 in group II. The difference was non- significant (P> 0.05). Conclusion: Longer perioperative analgesia duration, a quicker onset of sensory and motor block, and both were observed when 3 µg of dexmedetomidine was given to 6 mg of bupivacaine.