Background: Postpartum haemorrhage is the leading cause of maternal mortality and it has been estimated that 35% of maternal deaths are related to post- partum haemorrhage.Active management of the third stage of labour is the key and the incidence of post- partum haemorrhage is reduced with the use of prophylactic uterotonics. Prevention of PPH and its early management is most important mainly in developing countries and low resource healthcare settings to improve the quality of life of women. Aim & Objectives: To find out theeffectiveness and safety of carbetocin for the prevention of post- partum haemorrhageand to compare its efficacy with oxytocin for the prevention of post- partum haemorrhage.Material and Methods: A hospital based study was conducted among 200 females who delivered(both via NVD or C-section) inMuzaffarnagar Medical College & Hospital, Muzaffarnagar, Uttar Pradesh.Study was conducted for 18 months.Data was analysed statistically and chi square test was applied.Results:Mean age of women who received Carbetocin and oxytocinwas 29.05 years and 28 years respectively.Out of total women, who received carbetocin, 38% had PPH and out of total women, who received oxytocin, 53% had PPH and it was significantly associated. Nausea was more in women who received oxytocin as compared to women who received carbetocin, showing positive association. Conclusion: Our findings conclude that carbetocin is better than oxytocin in preventing PPH. Nausea as a side effect associated with carbetocin is also less as compared to oxytocin. The other side effects like vomiting and headache were more in women oxytocin but there is no significant association.