Aim: To investigate the alterations in blood pressure between postmenopausal and premenopausal women and evaluate the impact of menopause on cardiovascular parameters. Materials and Methods: This cross-sectional study included 60 postmenopausal and 60 premenopausal women with similar height and weight. Postmenopausal status was defined as a history of at least 12 months of amenorrhea. Participants with conditions such as dyslipidemia, surgical menopause, hypertension, or diabetes were excluded. Blood pressure measurements were taken using both palpatory and auscultatory methods with a mercury sphygmomanometer. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate were recorded and analyzed. Data were statistically evaluated using the Student’st-test. Results: The postmenopausal group showed significantly higher cardiovascular parameters compared to the premenopausal group. The pulse rate in postmenopausal women was 83.16 ± 1.45 beats/min compared to 80.76 ± 2.32 beats/min in premenopausal women (t = 3.35, p< 0.01). SBP was significantly elevated in postmenopausal women (120.54 ± 2.56 mmHg) compared to premenopausal women (118.45 ± 3.23 mmHg) (t = 3.54, p< 0.0001). DBP was also higher in postmenopausal women (81.65 ± 2.23 mmHg) than in premenopausal women (80.34 ± 4.02 mmHg) (t = 2.21, p< 0.05). These findings suggest that menopause is associated with increased blood pressure and pulse rate, likely due to hormonal changes and vascular alterations. Conclusion: Postmenopausal women exhibited higher pulse rates, systolic blood pressure, and diastolic blood pressure compared to premenopausal women, indicating an increased cardiovascular risk post-menopause. These findings emphasize the importance of early identification and management of blood pressure changes in postmenopausal women to prevent long-term cardiovascular complications.