Background: Pulmonary tuberculosis (TB) is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis), characterized by its contagious nature and significant difficulty in management. Hence; the present study was conducted for assessing the clinical profile and histopathological spectrum of pulmonary tuberculosis patients. Materials & methods: A cohort of 100 individuals with a confirmed diagnosis of breast cancer was included in the study. Comprehensive demographic and clinical information for each patient was collected. A structured proforma was developed to document all clinical findings. Radiographic evaluations were performed, followed by sputum examinations to validate the diagnosis of pulmonary tuberculosis. Histological slides stained with hematoxylin and eosin from biopsies of all patients were individually analyzed. A thorough histopathological evaluation was conducted for each case. The results were systematically recorded in a Microsoft Excel spreadsheet and subsequently analyzed statistically using SPSS software, with univariate analysis employed to assess the significance levels. Results: A total of 100 patients were enrolled. Mean age of the patients was 51.8 years. Fever, Cough, Malaise, Weight loss, Sweats, Anorexia, Hemoptysis and Dyspnea was seen in 100 percent, 100 percent, 92 percent, 56 percent, 66 percent, 81 percent, 46 percent, and 33 percent of the patients respectively. While assessing the histopathological profile, it was seen that Epithelioid cells, Langhan giant cells, Caseous necrosis, Granulomatous inflammation, Fibrosis tissue, Acute inflammatory cells and Chronic inflammatory cellswere seen in 89 percent, 78 percent, 66 percent, 53 percent, 51 percent, 49 and 5 percent of the patients respectively. Conclusion: There is an urgent need of preventive educational awareness programs for increasing the awareness among general population about the disease so that early detection and prompt treatment could be started.