Background: Gestational diabetes mellitus (GDM) is common disorder affecting pregnancy. It is a disorder of carbohydrate metabolism which occurs during pregnancy. Indian women have increased risk of developing GDM, and leads to adverse Maternal and neonatal outcomes. Women with raised serum uric acid also termed hyperuricemia in pregnancy are interlinked with high incidence of unfavorable outcomes in pregnancy such as GDM. Hence this study is done to prove the utility of serum uric acid in early diagnosis of GDM by starting early treatment so as to reduce the complications in pregnant women. Methods: The antenatal women are screened for GDM by serum uric acid levels with gestational age <12 weeks. These antenatal women are followed up around 24-28 weeks and DIPSI test is done and evaluated for GDM . Results: In our study, serum uric acid cut–off of 4.2 mg/dl had a positive association with the DIPSI values with p value less than 0.05 (p=0.018). In this study, in the raised serum uric acid category, 8 (19%) were positive for DIPSI and among the normal serum uric acid category, 3 (4.4%) were positive for DIPSI. Thus, we observe from our study that elevated levels of uric acid during the first trimester is interlinked with the development of gestational diabetes. Conclusions: The diagnosis of serum uric acid level in first trimester as a predictor of GDM is easy and economical and it can be used as a screening test for prediction of GDM.