Background: First-trimester miscarriage, which is defined as pregnancy failure up to 13 complete weeks. The present study determined efficacy of Mifepristone in induction of first-trimester miscarriage. Materials & Methods: 106 patients with first-trimester miscarriage prior to the 14th week of gestationwere given repeatable doses of 800 mcg misoprostol vaginally. Parameters such as type of miscarriage, previous surgical interventions on uterus and time from previous delivery (years)were recorded. Results: Out of 106 patients, 86 had successful induction and 20 had unsuccessful induction. The difference was significant (P< 0.05). The number of miscarriages was 1 in 66 and 13 respectively, and >2 in 20 and 7 in successful and unsuccessful induction respectively. Missed abortion was seen in 54 and 12 and blighted ovum in 32 and 8 in successful and unsuccessful induction respectively. Previous surgical interventions on uterus was seen in 11 and 3 in successful and unsuccessful induction respectively. The time from previous delivery was 3.21 years and 3.82 years in successful and in unsuccessful induction respectively. The difference was significant (P< 0.05). Conclusion: Misoprostol pharmacological induction is a successful and safe treatment for first-trimester abortion.